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Construction of protein-responsive shRNA/RNAi control system using RNP motif
Construction of protein-responsive shRNA/RNAi control system using RNP motif
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机译:利用RNP基序构建蛋白质反应性shRNA / RNAi控制系统
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摘要
An object of the present invention is to provide an RNAi control system using an RNA-protein interaction motif. The present invention provides an shRNA comprising: a guide strand having a sequence complementary to a target sequence; a passenger strand which forms a duplex with the guide strand; and a linker strand which links the guide strand and the passenger strand, wherein the linker strand comprises an RNP-derived protein-binding motif sequence. The present invention also provides an RNAi control system comprising: the shRNA; and an RNP-derived protein which specifically binds to a protein-binding motif sequence in the shRNA.
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