Vectors and yeast strains for protein production: Ca2+ ATPase overexpression

摘要

Lower eukaryote host cells in which an endogenous or heterologous Ca²⁺ ATPase is overexpressed are described. Also described are lower eukaryote host cells in which a calreticulin and/or ERp57 protein are overexpressed. These host cells are useful for producing recombinant glycoproteins that have reduced O-glycosylation.