Inhibitor(s) of transporters or uptake of monoaminergic neurotransmitters

摘要

The present disclosure concerns a compound, or a pharmaceutically acceptable salt thereof, having a formula:; where at least one of R₁-R₄ is a heterocycle, at least one of R₁-R₄ is an aryl group coupled to the ring by a linker atom, functional group, or other moiety, or where none of R₁-R₄ is an amide, and any and all combinations thereof. Remaining R₁-R₄ substituents independently are aliphatic, substituted aliphatic, amine, substituted amine, aryl, substituted aryl, cyclic, substituted cyclic, halide, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, hydrogen or hydroxyl. A method for treating a subject also is provided comprising administering a disclosed compound or compounds, or a prodrug that is converted into the disclosed compound or compounds, or a composition comprising the compound, compounds, or prodrugs thereof, to a subject. A method for making disclosed compounds also is provided.