A novel and useful system and method of detecting the best candidate frames for diagnosis out of a series of coronary angiograms frames. The mechanism analyzes the motion of the visible arteries in the sequence of angiogram frames to identify the local minimas of the differences between sequential frames. Wavelet transform coefficients are generated for each frame and used to quantify the differences between every two sequential frames to detect minimal differences (which correspond to minimal motion). The optimal end-systole and end-diastole frames are selected from these local minima frames.
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