Dimeric compounds of the FGF receptor agonists (FGFR), its preparation method and its application in Therapeutics

摘要

Heterocyclic compounds derived from the dimerization of cellulose growth factor (or GFR) receptor. Its preparation procedure and its application in treatment. Requirement 1: agonis compound1. Among the descendant fund recipients conforming to the general formula (1): m1-l-m2 (1), M1 and M2 represent each single unit m and L equally or differently, and represent a joint liaison group connecting M1 and M2.It is characterized by that this single M-cell conforms to the general formula (2),The asterisk * indicates the link point between monomer and L-shaped can, and the link point of each 1m1 and 2M2 unit is above an R or R * alternative;R is a hydrogen atom (if the link point of L and M is above R2) or a group - CONH *;R1 represents hydrogen atom or c833318323 linear tar group; R2 represents a group - conh8322222 (if the link point of L and M is located in R) o-conh *;R3 represents a group - co8322; r8308;where R⁴ represents a hydrogen atom or a linear C₁₋₄ alkyl group; X is a halogen atom chosen from the fluorine, chlorine and bromine atoms; in the form of base or salt of addition to an acid or a base.