Pharmaceutical composition comprising phthalocyanine encapsulated in an Indian nanoesferas polu00cdmero and its process of preparation with control of the properties nanoparticuladas

摘要

Pharmaceutical composition comprising ftalocinanina Indian nanoesferas encapsulated in a polu00cdmero and its process of preparation with control of nanoparticuladas properties.The present invention relates to a composition consisting of phthalocyanine indium (inPC), being a photosensitizing hydrophobic, which in the present invention is encapsulated in nanoesferas of PLGA peg with diameters less than 200 nm and movement sanquu00ednea prolonged, Destin For the treatment of oncological diseases via intravenous administration by photodynamic therapy.As well as a process for the preparation of this composition.More specifically, this invention relates to a composition for the treatment of oncological diseases, as well as other diseases not cancer caused by viruses, bacteria or fungi through hydrophobic photosensitizers are encapsulated in nanoesferas of PLGA peg with diu00e2 Meters of less than 200 nm for administration via intravenose followed by irradiation of the diseased area.For fotooxidau00e7u00e3o of biomolecules.The invention also includes the process of preparation of nanoesferas of PLGA peg containing inPC with control of nanoparticuladas properties such as size, zeta potential, encapsulation efficiency of the CPI.Recovery efficiency of nanoesferas and residual percentage of colloidal stabilizer from the understanding of the influence doos parameters involved in the preparation of the nanoesferas through a factorial design, which allows to optimize the size of the nanoesferas to lower diameters. Prior to 200 nm.