DERIVATIVE INSULIN, OWNED SUGAR-DECREASING ACTIVITY AT ORAL APPLICATION, METHOD OF ITS OBTAINING AND DRUG FORM ON ITS BASIS

摘要

The invention relates to pharmacy and medicine, in particular to orally administered compositions of a biologically active substance, in particular supramolecular insulin oligopeptide ensembles for the treatment of diabetes mellitus, its complications. This system allows for 24 hours with a single oral administration to keep the blood glucose level at the physiological level (super-effect), and the system components become resistant to the action of enzymes and are small in size, able to be easily absorbed from the intestine. SUMMARY OF THE INVENTION A supramolecular composition — an ensemble of acylated oligopeptides — products of enzymatic hydrolysis of insulin — is used as the main active agents. The composition can be produced by industry in sufficient quantities, taking into account the availability of all components of the composition.