Method for stabilising botulinum neurotoxin, use thereof and pharmaceutical compositions and preparations comprising a botulinum neurotoxin and hyaluronic acid

摘要

The present invention pertains to pharmaceutical compositions which comprise a botulinum neurotoxin from Clostridium botulinum, the neurotoxin being free of the complexing proteins naturally present in the botulinum neurotoxin complex or being chemically modified or being modified by genetic manipulation. Moreover the pharmaceutical compositions of the instant invention have good stability and are advantageously formulated free of human serum albumin.