Quantification of Botulinum Neurotoxins A and B: From Method Development to Applications in Clinical Samples

摘要

Method demonstrates ability to quantitate activity of BoNT A and B separately and from same sample ensuring reproducibility. Quantitative MRM runs with Endopep-MS hold promise for providing complete solution for BoNT analysis. Future work to focus on other matrices (i.e. stool) and serotypes.