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Composition comprising suspension of red blood cells, therapeutic anti-tumour vaccine containing it and uses thereof
Composition comprising suspension of red blood cells, therapeutic anti-tumour vaccine containing it and uses thereof
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机译:包含红细胞悬液的组合物,包含其的治疗性抗肿瘤疫苗及其用途
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摘要
The invention relates to a composition which induces, in a host, a cytotoxic cell response directed against cells expressing an antigen, in particular tumor cells, and which comprises red blood cells containing said antigen. These red blood cells may be in the form of an immune complex with an immunoglobulin, in particular IgG, which recognizes an epitope at the surface of the red blood cells, and/or be heat-treated or chemically treated so as to promote phagocytosis of said red blood cells by dendritic cells. As a variant, the red blood cells may be xenogenic red blood cells. The invention also relates to a therapeutic especially anti-tumor vaccine containing such a composition.
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