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Novel octahydrothienoquinoline derivative, pharmaceutical composition comprising derivative ,and use of these
Novel octahydrothienoquinoline derivative, pharmaceutical composition comprising derivative ,and use of these
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机译:新型八氢噻吩并喹啉衍生物,包含该衍生物的药物组合物及其用途
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摘要
The present invention provides compounds represented by the general formula (I): or pharmaceutical acceptable salts thereof, wherein R 1 is cyano or the like; R 2 and R 3 are hydrogen or the like; R 4 is C 1-6 alkyl or the like; R 5 is C 1-6 alkyl, halo-C 1-6 alkyl, cycloalkyl, cycloalkyl-C 1-6 alkyl, aralkyl or the like; R 6 and R 7 are each hydrogen, C 1-6 alkyl, halo-C 1-6 alkyl, cycloalkyl, C 1-6 alkoxy-C 1-6 alkyl, R 12 R 13 N-C 1-6 alkyl or the like, which exhibit potent dopamine D 2 receptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.
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机译:本发明提供由通式(I)表示的化合物或其药学上可接受的盐,其中R 1是氰基等; R 2和R 3为氢等。 R 4为C 1-6烷基等。 R 5为C 1-6烷基,卤代-C 1-6烷基,环烷基,环烷基-C 1-6烷基,芳烷基等; R 6和R 7分别为氢,C 1-6烷基,卤代-C 1-6烷基,环烷基,C 1-6烷氧基-C 1-6烷基,R 12 R 13 NC 1-6烷基等,表现出有效的多巴胺D 2受体刺激活性。本发明还提供了包含所述化合物的药物组合物及其用途。
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