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COVALENT ATTACHMENT OF LIGANDS TO NUCLEOPHILIC PROTEINS GUIDED BY NON-COVALENT BINDING
COVALENT ATTACHMENT OF LIGANDS TO NUCLEOPHILIC PROTEINS GUIDED BY NON-COVALENT BINDING
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机译:通过非共价结合指导配体对核蛋白的价均连接
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摘要
A covalently reactive ligand analogue (CAL) of formula (1): wherein, L1...Lx...Lm are components defining a ligand determinant, LX is a componentunit of the ligand determinant selected from the group consisting of an aminoacid residue, sugar residue, a fatty acid residue and a nucleotide, L' is afunctional group of LX, Y" is atom, covalent bond or linker, Y' is an optionalcharged or neutral group Y is a covalently reactive electrophilic group thatreacts specifically with a receptor that binds to said ligand determinant, andn is an integer from 1 to 1000 m is an integer from 1 to 30.
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