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N-(HETEROARYL)-1H-INDOLE-2-CARB0XAMIDE DERIVATIVES AND THEIR USE AS VANILLOID TRPV1 RECEPTOR LIGANDS
N-(HETEROARYL)-1H-INDOLE-2-CARB0XAMIDE DERIVATIVES AND THEIR USE AS VANILLOID TRPV1 RECEPTOR LIGANDS
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机译:N-(杂芳基)-1H-吲哚-2-碳酰胺衍生物及其作为香草醛TRPV1受体配体的用途
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摘要
The invention relates to compounds of general formula (I): wherein n is 0, 1, 2 or 3; X1, X2, X3, X4, Z1, Z2, Z3, Z4 and Z5 represent a hydrogen atom or certain specific substituents; W represents a fused bicyclic group of formula: attached to the nitrogen atom at the 1, 2, 3 or 4 positions; A represents an optionally substituted 5- to 7-membered heterocycle comprising from one to three heteroatoms selected from O, S or N. These compounds are TRPV1 vanillide receptor ligands useful in particular for the treatment of pain and inflammation.
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