An in-vitro process for the quick determination of the infection status of an infection with an influenza virus type

摘要

An in-vitro process for the quick determination of the infection status of an infection with an influenza virus type from whole blood in terms of an acute influenza infection or a pre-immunized latent influenza infection, comprising the steps of: • stimulating an antigen-specific T cell that is present in a first sample of whole blood with antigens of the influenza virus type, optionally in the presence of antibodies against CD28, or CD28 and CD49d; • processing of the influenza antigens by antigen-presenting cells (APC) by incubation for a sufficient time, in particular by incubation of at least 1 h, particularly of 1.5 h to 2.5 h, especially for 2 h, at 35 °C to 39 °C, especially at 37 °C, optionally with adding CO