首页> 外国专利> REVERSIBLE INHIBITORS OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE AND USES THEREOF

REVERSIBLE INHIBITORS OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE AND USES THEREOF

机译：S-腺苷-L-高半胱氨酸水解酶的可逆抑制剂及其用途

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摘要

1. The present invention provides compositions and methods for reversibly inhibiting S-adenosyl-L-homocysteine (SAH) hydrolase. The compounds of the present invention can be used as an anti-hemorrhagic viral infection agent, an immunosuppressant, a homocysteine lowering agent, or an anti-neoplasm agent. The compositions and methods of the present invention can be used for the prevention and treatment of hemorrhagic virus infection, autoimmune diseases, autograft rejection, neoplasm, hyperhomocysteineuria, cardiovascular disease, stroke, Alzheimer's disease, multiple sclerosis or diabetes. The compound of the present invention and/or used in the present invention has the formula (I):

机译：1.本发明提供了可逆地抑制S-腺苷-L-高半胱氨酸（SAH）水解酶的组合物和方法。本发明的化合物可用作抗出血性病毒感染剂，免疫抑制剂，高半胱氨酸降低剂或抗肿瘤剂。本发明的组合物和方法可用于预防和治疗出血性病毒感染，自身免疫性疾病，自体排斥反应，肿瘤，高同型半胱氨酸血症，心血管疾病，中风，阿尔茨海默氏病，多发性硬化或糖尿病。本发明和/或用于本发明的化合物具有式（I）：

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公开/公告号EP1613628B1

专利类型
公开/公告日2013-11-20

原文格式PDF
申请/专利权人 GENERAL ATOMICS;
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申请/专利号EP20040775883
发明设计人 YUAN CHONG-SHENG;
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申请日2004-04-09
分类号C07D473/34;C07D473/16;C07D473/40;A61K31/52;A61K31/522;A61P35;A61P31/20;A61P37/06;A61P25/28;A61P3/10;
国家 EP
入库时间 2022-08-21 15:52:05

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