首页> 外国专利> METHOD OF SCREENING ANTI-PLASMODIAL ACTIVITY OF ACRIFLAVIN AND ACRIFLAVIN AS AN ANTI-MALARIAL AGENT

METHOD OF SCREENING ANTI-PLASMODIAL ACTIVITY OF ACRIFLAVIN AND ACRIFLAVIN AS AN ANTI-MALARIAL AGENT

机译：筛选作为补充剂的阿维黄素中阿维黄素的抗血浆活性的方法

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摘要

The present invention provides a method of screening anti-plasmodial activity of Acriflavin, comprising assessing growth inhibition of Plasmodium in vitro in chloroquine susceptible and cloroquine resistant Plasmodium by Acriflavin; or measuring in-vivo Plasmodium killing ability of Acriflavin; assessing localization of Acriflavin at different stages; and analyzing effect of Acriflavin on gyrase activity wherein said method utilizes Acriflavin in nano-molar range. The present invention relates to potency of Acriflavin(Acriflavin) as an anti-malarial agent both in vitro parasite culture as well as in vivo. More specifically, the invention relates to a method o determining anti-plasmodial activity, Acriflavin as potent anti-malarial agent and also relates to composition(s) comprising Acriflavin.

机译：本发明提供了一种筛选Acriflavin的抗疟原虫活性的方法，该方法包括评估Acriflavin在易受氯喹和氯吡喹抗性的疟原虫中体外对疟原虫的生长抑制。或测量Acriflavin的体内疟原虫杀死能力;评估Acriflavin在不同阶段的定位;并分析了丙烯醛黄酮对促旋酶活性的作用，其中所述方法利用纳摩尔浓度范围内的丙烯醛黄素。本发明涉及Acriflavin（Acriflavin）作为抗疟疾药的体外寄生虫培养以及体内的效力。更具体地，本发明涉及确定抗疟原虫活性的方法，将阿克里黄素作为有效的抗疟剂，并且还涉及包含阿克里黄素的组合物。 展开▼

著录项

公开/公告号WO2014030171A9

专利类型

公开/公告日2014-10-30

原文格式PDF

申请/专利权人 DHAR SUMAN KUMAR;
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申请/专利号WO2013IN00411

发明设计人 DANA SRIKANTA;PRUSTY DHANESWAR;DAR ASHRAF;MUKHOPADHYAY PRITAM;
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申请日2013-07-04

分类号G01N33/569;A61K31;

国家 WO

入库时间 2022-08-21 15:51:31

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