NOVEL COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF INHIBITING ACTIVITY OF 11??-HSD1 (11??-HYDROXYSTEROID DEHYDROGENASE TYPE 1) ENZYME, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT

摘要

It has the ability that 11beta-HSD1 enzymes or its pharmaceutically acceptable salt and preparation method and its pharmaceutical composition is inhibited to contain them as active constituent the present invention relates to a kind of noval chemical compound. The compound of the present invention selectively inhibits the active dehydrogenase type 1 (11beta-HSD1) of 11beta-Hydroxysteroid dehydrogenase, therefore therapeutic agent can be effectively served as treating the 11beta-HSD1 by overactivity, such as noninsulin dependent 2) patients with type Ⅰ DM, insulin resistance, obesity, lipid disorders, metabolic syndrome, diseases and conditions cause by excessive glucocorticoid activity. ;The 2014 of copyright KIPO submissions