Novel compounds or pharmaceutically acceptable salts thereof inhibiting activity of 11amp;bgr;-HSD1 (11amp;bgr;-Hydroxysteroid dehydrogenase type 1) enzyme, preparation method thereof and pharmaceutical composition containing the same as an active ingredient

摘要

11 -HSD1 enzyme of the present invention has inhibitory activity of novel compounds or derivatives pharmaceutically acceptable salts , their preparation and relates to pharmaceutical compositions containing them as an active ingredient , a compound according to the present invention are 11 -HSD1 (11 -Hydroxysteroid dehydrogenase type 1) by selectively inhibiting the activity 11 - diseases caused by the activity of HSD1 , useful , for example, non-insulin dependent type 2 diabetes , insulin resistance , obesity , lipid disorders , metabolic syndrome , and as a therapeutic agent for the treatment of diseases and conditions mediated by excessive glucocorticoid action it can be used .