Identification Method of Metabolites and Enzymes for Prediction and Drug Evaluation in Female-Pattern Baldness

摘要

The present invention is a steroid hormone in the female pattern hair loss appears specifically to evaluate the urinary steroid hormones and hair determine, as a technique for predicting female pattern hair loss, as well as in related therapeutic development to provide a surface to evaluate the effectiveness of the drug, more specifically, extract the steroid hormone from the urine and a small amount of hair by sonication, the copolymer re-extracted using a solid phase extraction method was used as the adsorbent, and then trimethylsilyl derivatization by applying the reaction gas chromatography-mass concentration of steroid hormones and organs analyzed by the analyzer to measure the activity of the enzyme in female pattern hair loss prediction and related therapeutic development relates to an analysis method for the evaluation of drug efficacy. Accordingly, the invention is a small amount of urine, and effectively extracted from the hair, and steroid hormone analysis can determine the overall metabolic as well as the distribution tends to indicate the ratio of steroid hormone involved in the metabolism, biological evaluation and judgment indicators of female pattern hair loss, as well as Female Hair Loss in drug development can be used to evaluate drug efficacy. ;