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Non-steroidal anti-inflammatory drug patch having improved penetration rate thereof by concentration gradient in matrix
Non-steroidal anti-inflammatory drug patch having improved penetration rate thereof by concentration gradient in matrix
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机译:通过基质中的浓度梯度提高其渗透率的非甾体类抗炎药贴剂
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摘要
PURPOSE: A patch composition for improving skin permeability of a non-steroidal anti-inflammatory drug is provided to remarkably improve skin permeability of the drug. CONSTITUTION: A patch composition of non-steroidal anti-inflammatory drug(NSAID) with improved skin permeability contains: a support(1) containing 120 wt% of non-steroidal anti-inflammatory drugs, 0.1-10 wt% of dissolution agent, 0.1-5 wt% of dissolution aids, 0.1-20 wt% of absorbefacients, and 40-80 wt% of adhesive polymers for supporting the drugs; an adhesive layer(2) for helping adhesion with the skin; a drug saturation layer(3) containing the drugs which are saturated in a crystalline phase or at high concentration in a matrix; a multi-layered or mono-layered drug dispersion layer(4) containing the drugs dispersed in the matrix; and an exfoliation layer(5).
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