FLAVONE COMPOUNDS WITH 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE INHIBITORY ACTIVITY AND USES THEREOF

摘要

The present invention relates to a PGE ₂ composition for the prevention and treatment of disease requiring increased, alopecia, scalp improvement, and skin regeneration cosmetic composition for use, and the skin care composition containing a flavone compound as an effective ingredient, more specifically, the present 7, 3 'of the invention, 4'-trimethoxy flavone was cytotoxic ever, to inhibit the enzyme 15-PGDH which effectively metabolize the PGE _2, and controls the level of the cell and out of the associated PGE ₂ in wound healing molecules of COX-1/2, MRP4, and by controlling the expression of the mRNA PGT PGE ₂ inside and outside the cell _{By controlling the level improves the wound healing capacity and composition for preventing and treating a disease by having the effect of treating a disease associated with PGE 2 increasing need for PGE 2 increase, loss of hair, scalp improvement, and skin regeneration cosmetic composition for use, and It can be effectively used as an active ingredient in skin care compositions. ;}