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Methods for Stereoselective Synthesis of Tetrabenazine

机译：川tra嗪的立体选择合成方法

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摘要

invention L - proline include the use of asymmetric organic catalysts by Mannich - Michael reaction proceeds stereoselectively to the (+) - a method for synthesizing tetra vena binary . The method of the present invention conventional stereoselective (+) - tetrahydro vena spirit high efficiency compared to the synthesis method , a low-cost and environmentally friendly way . The invention is used in the treatment of Huntington's chorea and so on (+) - tetrahydro vena spirit provides new stereoselective synthesis method

机译： L -脯氨酸的发明包括使用不对称有机催化剂，通过Mannich-Michael反应立体选择性地合成（+）-一种合成四腔二元的方法。本发明的方法与合成方法相比，是常规的立体选择性（+）-四氢腔静脉麻醉的高效率，是一种低成本且环保的方式。本发明用于治疗亨廷顿舞蹈病等（+）-四氢通气灵提供了新的立体选择性合成方法 展开▼

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公开/公告号KR101409335B1

专利类型

公开/公告日2014-06-23

原文格式PDF

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申请/专利号KR20110081659

发明设计人 정재경;이희순;서영거;곽재환;백승만;
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申请日2011-08-17

分类号C07D455/06;C07D455/08;C07D471/04;A61K31/4375;

国家 KR

入库时间 2022-08-21 15:40:40

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