A Novel Hansenula polymorpha Gene Coding for Protein O-mannosyltransferase and Hansenula polymorpha Mutant Strain Deficient in The Same Gene

摘要

the present invention is a recombinant heterologous protein production strain century nulra poly Maurepas only nosil of protein O- transferase relates to a novel gene of . The invention also relates to a method of producing a recombinant heterologous protein is O- only nosil painter reduced using the novel protein transferase gene O- only nosil deficient century nulra poly Maurepas mutant and the mutant strains . Century there nulra poly Maurepas mutant strain of the present invention is a yeast -specific O- nosil painter is only reduced by a host cell can be developed that can be used to produce recombinant protein originally held by a foreign protein activity . ;