MEANS FOR STIMULATING TISSUE REGENERATION BY ATTRACTING MESINCHEMIC STEM CELLS AND / OR PLURIPOTENT BONE MARROW STEM CELLS IN BLOOD

摘要

1. An tissue regeneration promoting agent comprising any of: (a) an HMGB1 protein; (b) a cell that secrets an HMGB1 protein; (c) a vector into which a DNA encoding an HMGB1 protein is inserted; (d) an HMGB2 protein (e) a cell that secrets the HMGB2 protein; (f) a vector that embeds DNA encoding the HMGB2 protein; (g) a protein HMGB3; (h) a cell that secrets HMGB3 protein; (i) a vector that embeds DNA encoding the HMGB3 protein ; (j) S100A8 protein; (k) a cell that secrets S100A8 protein; (l) a vector that integrates DNA encoding S100A8 protein; (m) S100A9 protein; (n) a cell that secrets S100A9 protein; (o) ve ctor, in which DNA encoding S100A9 protein is inserted; (p) extract of cells or tissues; and (q) a heparin binding fraction of an extract of cells or tissues; wherein the agent is introduced into tissue other than tissue requiring regeneration. 2. The agent according to claim 1, which is administered parenterally. The tool according to claim 2, which is administered by injection. The tool according to claim 1, which is administered intravascularly, intramuscularly, subcutaneously, intradermally or intraperitoneally. A tool according to any one of claims 1 to 4, wherein the cell or tissue extract is obtained by a method comprising the step of immersing the cell or tissue in a solvent. The agent according to any one of claims 1 to 4, wherein the heparin binding fraction of the cell or tissue extract is prepared by a process comprising the steps of: (a) immersing the cell or tissue in a solvent; (b) contacting the immobilized heparin with the extract obtained in step (a); and (c) eluting the heparin binding fraction from immobilized heparin. 7. A tool according to any one of claims 1 to 4 for use in stimulating the regeneration of nerve, bone or skin tissue. A method for stimulating tissue regeneration, which comprises the step of administering an effective