COMBINATION OF α2-ADRENERGIC RECEPTORS AND NONSTEROID ANTI-INFLAMMATORY AGONISTS TREATMENT OR PREVENTION OF INFLAMMATORY SKIN DISEASE

摘要

1. A method of treating or preventing an inflammatory skin disease or a symptom and / or symptom associated with said disease in a subject, comprising topically applying a topical composition to a subject's skin area comprising a therapeutically effective amount of an α2-adrenergic receptor agonist, a therapeutically effective amount of a non-steroidal an anti-inflammatory agent and a pharmaceutically acceptable carrier, wherein the area of the skin is susceptible to or may be affected by an inflammatory skin disease and whether a symptom associated with the indicated disease. 2. The method according to claim 1, wherein the α2-adrenergic receptor agonist is selected from the group consisting of: (1) a compound of formula (I) wherein each of R, R and R is independently hydrogen, halogen, alkyl or alkoxy; each of R and R is independently hydrogen, alkyl or alkoxy; and each of R and R is independently hydrogen, nitro, alkyl or alkoxy; (2) a compound of formula (II) wherein each of A, A and A is independently hydrogen or alkyl; and independently is hydrogen or hydroxy; (3) a compound of formula (III) wherein each of B, B and B is independently hydrogen, hydroxy or alkoxy; and each of B and B is independently hydrogen or alkyl; (4) a compound of formula (IV) and (5) a compound of formula (V) 3. The method according to claim 1, wherein the α2-adrenergic receptor agonist is selected from the group consisting of brimonidine, (8-bromoquinoxalin-6-yl) - (4,5-dihydro-1H-imidazol-2-yl) amine, (8-bromoquinoxaline -5-yl) - (4,5-dihydro-1H-imidazol-2-yl) amine, (5-bromo-3-methylquinoxalin-6-yl) - (4,5-dihydro-1H-imidazol-2- il) amine, (5-bromo-2-methoxyquinoxalin-6-yl) - (4,5-dihydro-1H-imidazol-2-yl) amine, (4,5-dihydro-1H-imidazol-2-yl) - (8-methylquinoxalin-6-yl) amine, (4,5-dihydr