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METHOD FOR PREVENTION AND / OR TREATMENT OF FIBROSIS AND / OR REMOVAL OF THE CORNETAL (OPTIONS), METHOD FOR PRODUCING A PHARMACEUTICAL COMPOSITION FOR PREVENTION AND / OR TREATMENT OF FIBROSIS AND / OR REMOVAL PRACTICE
METHOD FOR PREVENTION AND / OR TREATMENT OF FIBROSIS AND / OR REMOVAL OF THE CORNETAL (OPTIONS), METHOD FOR PRODUCING A PHARMACEUTICAL COMPOSITION FOR PREVENTION AND / OR TREATMENT OF FIBROSIS AND / OR REMOVAL PRACTICE
1. The use of a peptide that inhibits TGF-β1 and is characterized by the amino acid sequence of SEQ ID NO: 6, for the prevention and / or treatment of corneal fibrosis and / or corneal opacity. The use of a peptide that inhibits TGF-β1 and is characterized by the amino acid sequence of SEQ ID NO: 6, in the manufacture of a pharmaceutical composition for the prevention and / or treatment of corneal fibrosis and / or corneal opacity. 3. A method for the prevention and / or treatment of corneal fibrosis and / or corneal clouding, comprising administering to a subject in need of treatment a therapeutically effective amount of a TGF-β1 inhibiting peptide and characterized by the amino acid sequence of SEQ ID NO: 6.4. An ophthalmic pharmaceutical composition comprising a therapeutically effective amount of a peptide that inhibits TGF-β1 and characterized by the amino acid sequence of SEQ ID NO: 6, and a pharmaceutically acceptable carrier suitable for ophthalmic administration, and made in the form of a local pharmaceutical composition containing hyaluronic acid or a pharmaceutically acceptable salt thereof .
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机译:1.抑制TGF-β1且特征在于SEQ ID NO:6的氨基酸序列的肽在预防和/或治疗角膜纤维化和/或角膜混浊中的用途。抑制TGF-β1并以SEQ ID NO:6的氨基酸序列为特征的肽在制备用于预防和/或治疗角膜纤维化和/或角膜混浊的药物组合物中的用途。 3.一种用于预防和/或治疗角膜纤维化和/或角膜混浊的方法,其包括向需要治疗的受试者施用治疗有效量的TGF-β1抑制肽,并且其特征在于SEQ ID NO:1的氨基酸序列。否:6.4。眼科药物组合物,其包含治疗有效量的抑制TGF-β1且特征在于SEQ ID NO:6的氨基酸序列的肽,和适于眼科给药的药学上可接受的载体,并以局部药物形式制成含有透明质酸或其药用盐的组合物。
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