TWO-STRANDED RNA MODIFIED WITH LIPIDS AND HAVING POWERFUL EFFECT OF RNA INTERFERENCE

摘要

FIELD: biotechnologies.;SUBSTANCE: invention describes two-stranded RNA modified with lipids and including antisense thread, the nucleotide sequence of which is complementary to target sequence in the target gene, and a sense thread, the nucleotide sequence of which is complementary to antisense thread. A two-stranded lipid is connected to the first nucleotide on the 5'-end of sense thread, either directly or through a linker. RNA has high stability to action of nuclease and is effectively absorbed with a cell, as well as generates excellent effect of RNA interference.;EFFECT: improvement of efficiency.;15 cl, 14 dwg, 3 ex