Structural Features of Totally Designed Lipidic Materials for Small Interfering RNA Delivery System: Glutamate-Based Lipidic Materials as Potential siRNA Carriers

摘要

RNA interference (RNAi) with siRNA has been revealed as a powerful technique that is capable of suppressing targeted genes with high specificity. A delivery system for siRNA into mammalian cells has broadened the scope of medical intervention since siRNA has recently emerged as potential therapeutic agents in the treatment of human genetic and nongenetic diseases. Several studies have reported various strategies for the siRNA delivery system. Viral vectors are accepted as the most effective tools forgene transfer into mammalian cells in vivo and in vitro. However, there are safety problems such as induction of immune reactions or tumorigenesis. Therefore, the use of nonpathogenic materials based on lipids or polymers has been attempted. Recently, avariety of studies have been exploring the novel nonpathogenic materials as potential siRNA carriers. Understanding of lipidic materials for small interfering RNA (siRNA) delivery system is essential for the effective design and selection of appropriatematerials as potential applications in basic and therapeutic research.