METHOD FOR ASSESSING GENETIC MORPHOFUNCTIONAL DISORDERS IN WHITE RAT OFFSPRING WITH CHEMICAL GENETIC BURDEN

摘要

FIELD: medicine.;SUBSTANCE: white rat offspring behaviour after a toxic exposure is studied with an open-field test. The number of sniffing, locomotion, in-place acts are recorded. A prognostic index is calculated by formula: P=1/(1+e^-y), wherein P is the prognostic index that is a probability of genetic variations; e is a mathematical constant equal to 2.72; y is a regression equation: y=7.04-0.65X₁+1.45X₂-0.64X₃, wherein numerical values are constants and regression coefficients; X₁ is the number of sniffing acts; X₂ is the number of locomotion acts; X₃ is the number of in-place acts. If P is more than 0 and less than 0.5, a probability of the genetic variation is stated as minimal, while P more than 0.5 and less than 1 shows a probability of the genetic variations stated as high.;EFFECT: method extends the range of methods for assessing the genetic disorders in experimental animals.;1 tbl, 2 ex