FUSED DLK1-Fc PROTEIN AND USING IT FOR METASTASES INHIBITION, POLYNUCLEOTIDE CODING PROTEIN, VECTOR, HOST CELL, METHOD FOR PRODUCING FUSED PROTEIN, COMPOSITION AND METHOD FOR METASTASES INHIBITION

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: presented group of inventions refers to biotechnology, and concerns a DLK1-Fc fused protein and using it for the metastases inhibition, a polynucleotide coding such a protein, an expression vector containing the polynucleotide, a host cell producing the above fused protein, a method for producing the fused protein by culturing the above host cell, a composition containing the above fused protein, and a method for the metastases inhibition. The characterised fused protein contains a DLK1 extracellular soluble domain consisting of the amino acid sequence SEQ ID NO:4 and Fc domain of a human antibody.;EFFECT: group of inventions can be used for preparing a therapeutic agent for reduction of cancer cell migration and the metastases inhibition.;11 cl, 36 dwg, 3 ex