bispecific binding protein binding to at least two targets, bispecific binding protein conjugate, pharmaceutical composition, isolated nucleic acid, vector, host cell, method for producing a bispecific binding protein, method for determining a patient's reactivity to a therapeutic agent that is capable of modulating tlr activity, a method of activating or inhibiting a tlr9 responsive cell, a method of treating a patient in need of tlr9 activation or a tlr inhibition, and a method for identifying a tlr signaling inhibitor or enhancer. tlr

摘要

abstract "bispecific binding protein binding to at least two targets, bispecific binding protein conjugate, pharmaceutical composition, isolated nucleic acid, vector, host cell, method for producing a bispecific binding protein, method for determining the reactivity of a patient to a therapeutic agent that is capable of modulating the activity of a tlr, method for activating or inhibiting tlr9 responsive cells, method for treating a patient who needs tlr9 activation or tlr inhibition, and method for identifying a tlr inhibitor or stimulator. TlR Signaling "are genetically modified multivalent and multispecific binding proteins that bind to immune cell receptors and / or autoantigens, along with methods for production and uses in disease prevention, diagnosis, prognosis and / or treatment.