Compound with (1E, 6E) -1,7-bis- (3,4-dimethoxyphenyl) -4,4-disubstituted-hepta-1,6-diene-3,5-dione structure scaffold, its biological activity And cross-reference of applications related to its use

摘要

The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl) -propenal moiety. The compounds and compositions of the present invention include androgen-related physical conditions, androgen-related inflammation, wounds (compounds aid in wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and alopecia; Kennedy disease (bulb Spinal muscular atrophy or SBMA), polyglutamine-mediated motor neuron degeneration; cancers such as prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (hepatic) cancer and pancreatic cancer and others described herein Useful in the treatment or prevention of medical conditions, including medical conditions. For the treatment of such medical conditions, a therapeutically effective amount of the disclosed compound, derivative or pharmaceutical composition thereof is administered to an individual suffering from the medical conditions described herein. Administering either is included.