COMPOUNDS WITH (1E,6E)-1,7-BIS-(3,4-DIMETHOXYPHENYL)-4,4-DISUBSTITUTED-HEPTA-1,6-DIENE-3,5-DIONE STRUCTURAL SCAFFOLD, THEIR BIOLOGICAL ACTIVITY, AND USES THEREOF

摘要

The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention include androgen-associated symptoms, androgen-associated inflammation, wounds (the compounds aid in wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and medical conditions including alopecia; Kennedy's disease (spinal and soft muscular dystrophy or SBMA), polyglutamine-mediated motor neuron degeneration, prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (liver) cancer and pancreatic cancer; And other medical conditions described herein. Treatment of such medical conditions includes administering a therapeutically effective amount of any of the disclosed compounds, derivatives thereof, or pharmaceutical compositions thereof to an individual suffering from the medical conditions described herein.