High-efficiency nanoparticle-type double-stranded oligo RNA structure and method for producing the same

摘要

The present invention relates to a double-stranded oligo RNA structure and a method for producing the same, and more particularly, to improve the in-vivo stability of a double-stranded oligo RNA and improve cell transmission efficiency, the double-stranded oligo RNA The present invention relates to a double-stranded oligo RNA structure in which a polymer compound is linked to each other by a covalent bond and a method for producing the structure. The double-stranded oligo RNA structure having a structure optimized by the present invention does not inhibit the function of the double-stranded oligo RNA, and can efficiently improve the stability and cell membrane permeability of the double-stranded oligo RNA. Thus, double-stranded oligo RNA can be transferred into cells even at relatively low doses. In cancer and infectious diseases, not only double-stranded oligo RNA therapeutic tools but also new forms It can also be effectively used as a double-stranded oligo RNA transmission system.