RNA HIGH-EFFICIENCY NANOPARTICLE-TYPE DOUBLE-HELICAL OLIGO-RNA STRUCTURE AND METHOD FOR PREP ARING SAME

摘要

The present invention relates to a double-stranded oligo RNA construct and a method for producing the double-stranded oligo RNA construct. More particularly, the present invention relates to a double-stranded oligo- An RNA structure and a method of producing the structure. As described above, the double-stranded oligo RNA construct having the optimized structure does not inhibit the function of the double-stranded oligo RNA and can improve the stability of the double-stranded oligo RNA and the cell membrane permeation function efficiently. Therefore, Can also be used as a new type of double helix oligo RNA delivery system as well as a tool for the treatment of double helix RNA in cancer and infectious diseases because the double helix oligo RNA can be delivered into cells.