HIGH-EFFICIENCY NANOPARTICLE-TYPE DOUBLE-HELICAL OLIGO-RNA STRUCTURE AND METHOD FOR PREPARING SAME

摘要

The present invention relates to a double-helical oligo-RNA structure and a method for manufacturing same, and more specifically, to a double-helical oligo-RNA structure in which a polymeric compound is connected to the double-helical oligo-RNA by means of a covalent bond to improve the biosatbility of the double-helical oligo-RNA and enhance cell delivery efficency, and to a method for manufacturing the structure. In the double-helical oligo-RNA structure having the optimum structure, as described above, a function of the double-helical oligo-RNA is not compromised, and the double-helical oligo-RNA can be delivered to cells even with a small dose of relatively low concentration due to the stability of the double-helical oligo-RNA and efficient enhancement of a cell membrane penetration function, can be efficiently enhanced, and thus can be useful as a tool for treating double-helical oligo-RNA in cancer and infectious diseases and as a novel form of a double-helical oligo-RNA delivery system.