Second-generation virus-like particles derived from the Epstein-Barr virus for vaccination purposes (VLP)

摘要

The present invention relates to Epstein-Barr virus-like particles (EB-VLP) that are substantially free of Epstein-Barr virus (EBV) DNA. The present invention also includes (a) lacking at least one expressible gene selected from the group consisting of BFLF1 gene, BBRF1 gene, BGRF1 gene, BDRF1 gene, BALF3 gene, BFRF1A gene, and BFRF1 gene, and (b It also relates to a polynucleotide comprising an EBV genome that produces the EB-VLP of the invention in a suitable host cell. The present invention further relates to vectors and host cells comprising the polynucleotide of the present invention, methods for producing the EB-VLP, methods for producing the vaccine, vaccines and compositions containing the EB-VLP. [Selection figure] None