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HYBRID BACULOVIRUS HAVING THE CAPABILITY OF INFECTING AT LEAST THREE INSECT HOSTS AND USES THEREOF

机译：具有至少三种昆虫寄主感染能力的混合杆状病毒

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摘要

Disclosed herein is an Autographa californica multiple nucleopolyhedrovirus (AcMNPV) based hybrid baculovirus and its uses thereof. The AcMNPV based hybrid baculovirus is capable of infecting different hosts, and comprises Bombyx mori nuclear polyhedrosis virus (BmNPV) genes of lef9, vlf1, p6.9, and vp80; Maruca vitrata multiple nucleopolyhedrovirus (MaviMNPV) genes of lef2, orf1629, and pe38; and AcMNPV/BmNPV/MaviMNPV-hybrid genes of pk1, lef8, DNA pol, GP41, helicase, orf94, VP1054, orf65, lef4, lef5, and orf99. The AcMNPV based hybrid baculovirus is therefore useful as a bio-tool or bio-insecticide for its capability of delivering genes for production or expression of toxic proteins in at least three different insect hosts.

机译：本文公开了一种基于 Autographa californica 的多核多角体病毒（AcMNPV）的混合杆状病毒及其用途。基于AcMNPV的混合杆状病毒能够感染不同的宿主，并且包含lef9，vlf1，p6.9和vp80的 Bombyx mori 核多角体病毒（BmNPV）基因; Lef2，orf1629和pe38的 Maruca vitrata 多核多角体病毒（MaviMNPV）基因;以及pk1，lef8，DNA pol，GP41，解旋酶，orf94，VP1054，orf65，lef4，lef5和orf99的AcMNPV / BmNPV / MaviMNPV杂合基因。因此，基于AcMNPV的混合杆状病毒可用作生物工具或生物杀虫剂，因为它能够传递基因以在至少三种不同的昆虫宿主中产生或表达有毒蛋白质。 展开▼

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公开/公告号US2015252333A1

专利类型

公开/公告日2015-09-10

原文格式PDF

申请/专利权人 CHUNG YUAN CHRISTIAN UNIVERSITY;
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申请/专利号US201414277892

发明设计人 MEAN-SHINE CHEN;YING-JU CHEN;TZONG-YUAN WU;CHAO-YI TENG;
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申请日2014-05-15

分类号C12N7/00;

国家 US

入库时间 2022-08-21 15:24:49

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