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Cross-coupled peptide nucleic acids for detection of nucleic acids of pathogens
Cross-coupled peptide nucleic acids for detection of nucleic acids of pathogens
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机译:用于病原体核酸检测的交叉偶联肽核酸
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摘要
Disclosed is a method for lowering the detection limit in a method of detecting a nucleic acid comprising (i) contacting a solution comprising a first PNA with a substrate having a second PNA affixed thereto, the second PNA comprising at least one trans-cyclopentane residue, wherein the first PNA has two linker-attached biotins attached thereto and the first and second PNAs being complementary to different portions of a target DNA; (ii) contacting a sample suspected of containing the nucleic acid with the first and second PNAs; and (iii) determining the presence of the reporter molecule on the substrate. Also disclosed are a detection assay and a kit for detecting a target nucleic acid.
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