Phenanthroindolizidine compound and NFκB inhibitor containing same as active ingredient

摘要

A novel compound having an excellent NFκB inhibitory effect is provided and specifically disclosed is a compound represented by the following formula (1) or a salt thereof:;wherein, R¹ represents a hydrogen atom, a lower alkyl group, a lower alkyloxy group, or a halogen atom;;R² represents a hydroxyl group, or a lower alkyloxy group;;R³ represents a hydrogen atom, a lower alkyl group, or a halogen atom;;R⁴ represents a hydrogen atom or a lower alkyloxy group;;R⁵ represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R⁶ or an isopropylidenedioxy group formed together with R⁶;;R⁶ represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R⁵ or an isopropylidenedioxy group formed together with R⁵;;R⁷ represents a hydrogen atom or a lower alkyl group; and;R⁸ represents a hydrogen atom, a hydroxyl group, an amino group, or a lower alkylcarbonyloxy group (excluding the case where R¹, R³, R⁴ and R⁷ are hydrogen atoms, R² and R⁸ are hydroxyl groups, and R⁵ and R⁶ are methoxy groups).;