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Nucleobase-functionalized conformationally restricted nucleotides and oligonucleotides for targeting nucleic acids
Nucleobase-functionalized conformationally restricted nucleotides and oligonucleotides for targeting nucleic acids
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机译:核碱基功能化的构象受限核苷酸和寡核苷酸,可靶向核酸
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摘要
Embodiments are disclosed herein that involve C5-functionalized nucleic acids, which can be used for detecting a target in a nucleic acid. Particular embodiments disclose methods for making these compounds, wherein the compounds can be formed by coupling of an intermediate with a linker. Certain embodiments disclose the use of these compounds for detecting single nucleotide polymorphisms, and for increasing the thermal affinity of nucleic acid complements as compared to unmodified nucleic acid complements. In addition, the disclosed compounds can decrease enzymatic degradation of nucleic acids.
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