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Mutant and infectious yellow fever virus cdna, DNA construct, recombinant yellow fever virus and human vaccine against yellow fever infections.

机译：突变和传染性黄热病病毒cdna，DNA构建体，重组黄热病病毒和抗黄热病感染的人类疫苗。

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摘要

The present invention is related to a vaccine composition for humans against YF infections consisting essencially of a recombinant YF virus, YFiv5.2/DD, which is regenerated from YF infectious cDNA. There is provided new plasmids, pYF 5'3' IV/G1/2 and pYFM 5.2/T3/27, which together, have the complete sequence of said YF infectious cDNA. The method for producing recombinant YF virus and the Original, Primary and Secondary Seed Lots are other embodiments of the present invention. IMAGE

机译：本发明涉及用于人的抗YF感染的疫苗组合物，其基本上由重组YF病毒YFiv5.2 / DD组成，所述重组YF病毒是从YF感染性cDNA中再生的。提供了新的质粒pYF 5′3′IV / G1 / 2和pYFM 5.2 / T3 / 27，它们一起具有所述YF感染性cDNA的完整序列。产生重组YF病毒的方法以及原始，初级和次级种子批次是本发明的其他实施方案。 <图像>

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公开/公告号BRPI9701774B1

专利类型
公开/公告日2015-08-25

原文格式PDF
申请/专利权人 FUNDAÇÃO OSWALDO CRUZ (FIOCRUZ);
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申请/专利号BR19979701774
发明设计人 RICARDO GALLER;MARCOS DA SILVA FREIRE;
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申请日1997-04-11
分类号A61K39/12;C12N15/40;A61K39;C07K14/08;C07K14/18;C12N7;C12N7/01;
国家 BR
入库时间 2022-08-21 15:15:54

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