Method for the production of recombinant proteins in mammary Gland of mammals through the transformation of the mammary glandular epu00edtelio adeno-associated vectors.

摘要

The invention relates to a method that enables the production of recombinant proteins in the milk of non-transgenic mammals. The method is based on the direct transfer of the genetic information of interest to the cells forming the secretory mammary epithelium, by means of adeno-associated vectors. Using this method, it is possible to produce high levels of recombinant proteins in the milk of non-transgenic mammals during a complete lactation period. The method is scalable and enables sustained levels of expression to be achieved for periods of more than 100 days.