CLEAVABLE MODIFICATIONS TO REDUCIBLE POLY (AMIDO ETHYLENIMINES)S TO ENHANCE NUCLEOTIDE DELIVERY

摘要

Polyplex formulations were prepared using p(TETA/CBA) its PEGylated analog p(TETA/CBA)-g-PEG2k and mixtures of the two species at 10/90 and 50/50 wt % respectively. Increasing PEG wt% inhibited polyplex formation. This work demonstrates the feasibility of preparing homogenous polyplexes by altering the PEG wt% using a mixture of p(TETA/CBA) and p(TETA/CBA)-g-PEG2k products. Further a single-step method of making p(TETA/CBA)-g-PEG2k is disclosed