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Cleavable modifications to reducible poly(amido ethylenimine)s to enhance nucleotide delivery
Cleavable modifications to reducible poly(amido ethylenimine)s to enhance nucleotide delivery
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机译:可还原的聚(酰胺基亚乙基亚胺)的可切割修饰,以增强核苷酸的传递
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摘要
Improved poly(amido ethylenimine) copolymers for gene delivery are disclosed. One illustrative embodiment includes polyethylene glycol (PEG) covalently bonded to a branched poly(triethyenetetramine/cystamine bisacrylamide) copolymer (poly(TETA/CBA)). The polyethylene glycol can be linear or branched. Another illustrative embodiment includes an RGD peptide covalently bonded to the poly(TETA/CBA)-PEG conjugate. Still another illustrative embodiment includes a method of using these compositions for transfecting a cell with a nucleic acid.
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