ENGINEERING OF THERMOTOLERANT BACILLUS COAGULANS FOR PRODUCTION OF D

摘要

Genetically modified microorganisms having the ability to produce D( ) lactic acid at temperatures between 30�C and 55�C are provided. In various embodiments the microorganisms may have the chromosomal lactate dehydrogenase () gene and/or the chromosomal acetolactate synthase () gene inactivated. Exemplary microorganisms for use in the disclosed methods are Bacillus spp., such as Bascillus coagulans.