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Self assembling peptide nanoparticles as vaccines against infection with norovirus
Self assembling peptide nanoparticles as vaccines against infection with norovirus
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机译:自组装肽纳米颗粒作为诺如病毒感染的疫苗
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摘要
pSelf assembling peptide nanoparticles (SAPN) incorporating T cell epitopes and displaying the P domain of the norovirus protein VP1 are described. The nanoparticles of the invention consist of aggregates of a continuous peptide chain comprising two coiled coil oligomerization domains connected by a linker segment wherein one or both oligomerization domains incorporate T cell epitopes within their peptide sequence. These nanoparticles are useful as vaccines and adjuvants for the prevention and treatment of norovirus infections./p
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