TREATMENT AND PREVENTION OF DISEASES MEDIATED BY MICROORGANISMS VIA DRUG MEDIATED MANIPULATION OF THE EICOSANOID BALANCE

摘要

The invention provides a method of enhancing the efficacy of antibiotic treatment of tuberculosis trypanosomiasis leprosy and leishmaniasis involving co administering to a mammal undergoing antibiotic treatment therapeutically effective amounts of a first compound that is an inhibitor of 5 lipoxygenase and optionally a second compound that is a product of the cyclooxygenase pathways. The invention also provides a pharmaceutical composition comprising an antibiotic an inhibitor of 5 lipoxygenase and a product of the cyclooxygenase pathways.