COMPOSITIONS COMPRISING A SINGLE VARIABLE DOMAIN AND CAMOSTAT MESYLATE (CM)

摘要

The present disclosure provides a means of stabilising a single variable domain in particular in protease rich environments such as the stomach and intestine. A composition in particular a pharmaceutical composition comprising a single variable domain and camostat mesylate is provided together with uses of said composition as a medicament and in methods of treatment. Compositions of the disclosure are particularly useful in the topical treatment of gastrointestinal conditions such as Crohn's Disease or ulcerative colitis or for direct activity in the gut mucosal immune system.