SALMONELLA TYPHI TY21A EXPRESSING YERSINIA PESTIS F1 V FUSION PROTEIN AND USES THEREOF

摘要

Described herein is the generation of a plasmid construct for expression of a Fl- V fusion protein. In the disclosed plasmid , the F1- V fusion protein coding sequence is operably linked to the htrA promoter , and is fused in frame to the HlyA secretion signal sequence. Also described is serovar Typhi strain Ty21a containing the F1- V fusion protein expression plasmid , such as for use as an oral vaccine against plague.